FINDING THE RIGHT CBD DOSAGE

Updated: Jan 22

It seems that cannabidiol, better known as CBD, is being promoted as a therapy everywhere you go. You can find it in hundreds of supplements designed to ease all types of pain, inflammation, and anxiety. When you're looking for all-natural lifestyle-enhancing products, you can find CBD at the top of the list. CBD and other cannabinoids can be found in balms, massage oils, and tinctures. When choosing a CBD product, it is important that you select the right product to meet your needs and understand how to use it effectively.


The potential role of CBD in calming the symptoms of many common health problems, including inflammation, anxiety, depression, acne, and heart disease, have been studied. The CBD industry is growing rapidly, and the body of research is expanding by the day. However, there is still a lot of debate about the laws that regulate CBD, how CBD can be used safely and effectively, the quality of products on the market, and whether or not you can be sure you are getting what you are paying for.


CBD products with less than .3% THC are legal nationally in the US as a result of the 2018 Farm Bill. Still, the legal status of these products varies between states. CBD products are treated as a supplement at the federal level and therefore not regulated by the Food and Drug Administration (FDA) the same as they would a prescription drug. This lack of regulation results in:


1. An inconsistent amount of CBD per dose across brands can make it difficult to determine how much of the product equals the ideal dosage, and


2. A lack of oversight that can't guarantee you that you are getting what it says on the bottle.





All Entourage products are tested by a third party, so you know they contain what they say they do. However, it can still be challenging to determine the ideal dosage to meet your needs, especially for tinctures, but don't worry; we've got you covered.


This article will examine CBD dosage, including the studies into which dosages are safe and reliable. Also, factors that affect the CBD dosage you should take and the difference in dosages you should consider when seeking to relieve pain vs. anxiety.


By the end of this article, our hope is that you understand more about the factors that may influence what dose you should take. Furthermore, you feel confident in your ability to measure out the right dose, regardless of which CBD you purchase.


Note that the information given here is meant to act as a knowledgeable guide to help you come to the best decision for yourself. We want to stress, if you are using CBD to treat a severe medical condition, you should do so in consultation with your doctor. Especially if you are taking other medications that contain the "grapefruit warning" and are processed by the liver. This article does not intend to diagnose, treat, cure, or prevent any disease.


How CBD Works Inside The Body?

Our body's endocannabinoid system is comprised of three main components:


1. There are two cannabinoid receptors, CB1 and CB2.


· CB1 receptors are mainly located in the central nervous system (CNS, nerves connected to the spinal cord and across the brain). They are predominantly responsible for the neurological and emotional benefits of CBD, as well as our sense of pain.


· CB2 receptors are more prominent in our peripheral nervous system (PNS, outer nerves beyond the spinal cord and brain, such as those in your arms and legs, but these receptors can also be present in our CNS) and your immune cells.



2. Endogenic cannabinoids: are the cannabinoids that your body naturally produces.


3. Enzymes: These encourage the breakdown and use of cannabinoids.


Our body's natural endocannabinoids work on demand, which means that when our body creates inflammation and one of our internal systems gets out of wack, these natural compounds are also released to help return our bodies to homeostasis. These endocannabinoids fit like a key into the CB1 and CB2 receptors and influence the cell structures they are a part of to return to a balanced state.


Coincidently, the cannabis plant contains an array of cannabinoids that also interact with our body's natural endocannabinoid system. The two most commonly discussed cannabinoids are THC and CBD. While THC binds directly to the cannabinoid receptors mimicking and disrupting the endocannabinoid system, making you feel high, CBD does not. Instead, CBD augments the receptors, preventing inflamed compounds from binding excessively and allowing the inflammation to dissipate. CBD modulates the 5HT serotonin and the TRPV1 receptors in animals responsible for pain and inflammation and could be a meaningful solution for complex conditions with neuropathic pain.


Factors Affecting CBD Dosage:

One of the most important things to consider that impacts CBDs effectiveness is how you are consuming CBD. These typically fall into 4 main categories:


· Topical - External, applied directly to the area of concern

· Ingestible - Absorbed through the stomach

· Sublingual - Absorbed through the capillaries under the tongue

· Inhalation - Absorbed through the lungs after smoking vape products or CBD flower


At Entourage, we believe the safest and most effective way to consume CBD is via tinctures sublingually, sometimes combined with a topical application to treat localized severe pain, and here is why: bioavailability.


For the purposes of this article, we want to focus on identifying the right tincture dosage, but if you are interested in why we think sublingual tinctures are the best method available today, read our article on CBD and bioavailability (Coming Soon)


Tincture Dosage, How much CBD should I take?

Taking one - 1mL dropper of CBD a day is the most common dose recommendation. Unfortunately, you cannot say whether it is the right dose for anyone because several variables influence what the right dose for you might be. There have been many studies conducted on CBD dosages for various symptoms. In 2019, A systematic review of cannabidiol dosing in clinical populations was published on the NIH website.


There are several things to consider when determining the right dosage for you, but we think the 3 most important are:

· Body Weight,

· The Severity of the Symptoms, and

· Other Medications and Potential Side Effects


Body Weight:

Similar to many other supplements and medication, the dosage of CBD taken should be calculated based on the consumer's body weight. This is particularly important for CBD because it is a fat-soluble compound stored in your body's fat cells.


CBD and other cannabinoids work best when you have enough of them in your system to create build-up, causing your body to store the excess cannabinoids away in your fat cells for gradual release as needed. Remember, the endocannabinoid systems' job in the body is to maintain balance across your different systems. Because there is a need for this build-up to occur, we recommend starting with double the recommended dosage that you decide is right for you. This will help you feel relief sooner as you will likely need to consume the required dose for relief and then a little extra to fill the reserves. Don't worry; research has shown that there is no risk of overdose associated with CBD consumption. And "Chronic use and high doses of up to 1500 mg per day have been repeatedly shown to be well tolerated by humans."




The Severity of the Symptoms

It is also essential to consider the severity of the symptoms you are attempting to address with your CBD supplement. Chronic pain and severe stress, anxiety, or depression are signs of an extreme imbalance in your body and will take a greater CBD dose to achieve the desired effect. We want to stress, though, if you are dealing with these issues and considering CBD as a part of your wellness strategy, you should consult a medical professional and not self diagnose and prescribe. These symptoms are often related to larger issues impacting the body. While CBD may provide the relief you need now, it can also mask or hide issues until they become a much more significant concern.


Your body may only be a little off balance and thus need only a small amount of CBD if the symptoms you have are mild and non-medical. More serious conditions can also be helped with CBD at higher dosages. Combining both topical and ingested methods can also lead to some enormous benefits for those suffering from chronic pain.


While we want you to consult a medical professional to determine the right treatment for you, we are also excited about the growing body of research. Research shows that CBD has been found to support improvements in all of the following conditions:


· Pain and Inflammation

· Stress, Anxiety, and Depression

· Cancer Related Symptoms

· Acne and Other Skin Disorders

· Epilepsy

· Multiple Sclerosis

· Parkinson's Disease

· Alzheimer's Disease

· Lowers High Blood Pressure and Reduces Risk for Cardiovascular Complications

· Schizophrenia and other Mental Disorders


Other Medications and Possible Side Effects

Many people have found CBD and other cannabinoid products to be a great addition to their wellness regimen, frequently in conjunction with medications that patients take to deal with their specific illness, condition, or disease. While there are certainly stories of people that were able to wean themselves off heavy narcotics and substitute with CBD; We can't stress enough that if you are currently taking any other medications and are considering including CBD in your routine, you need to discuss this with your doctor to fully understand any potential side effects that may occur.


CBD is ultimately processed in the liver. It is crucial that those who take other medications containing the "grapefruit warning" are working in close consultation with their physician and regularly monitoring blood work to ensure no adverse complications.


The sedation effects of CBD can be enhanced if combined with alcohol and other central nervous system depressants. You should certainly ask a medical professional if it is safe before combining alcohol and other medications with CBD.



Taking CBD for the First Time

If you are taking CBD for the first time, we recommend using the dosage chart above to help you determine the recommended dosage. However, for the very first dose, we recommend that you double it to give the cannabinoids a chance to build up in your fat cells. This allows the cannabinoids to be gradually released when they are needed to balance your body's systems.


Some find that a double dose is still not enough to find relief on their first dose, in which case we recommend increasing each successive dose (3x, 4x, and 5x) until you find relief. Suppose you reach a 5x dose, have taken a 2x-3x dose regularly for more than 14 days, and not find the relief you were hoping for. In that case, we recommend consulting your doctor about higher dosages or the possibility that CBD might not be the right choice for you.


After taking CBD, effects are typically felt within 30 minutes to 1 hour and can last between 2 and 8 hours. Once you have determined that your dose has taken effect and found sufficient relief, your next successive doses should be used to determine your minimum effective dose.


Decrease each successive dose by 10% and evaluate its effectiveness. The minimum effective dose will vary for everyone. Some have found that dosages as low as 5mg are effective, and others need 300mg+ to find the relief they need.



Calculating Your CBD Dosage

Tinctures come in all different concentrations and sizes; for this reason, you must read the label carefully to determine how many mg of CBD are in 1 mL of CBD Oil. The most common tincture is probably the 1000mg 1-ounce tincture. Typically these bottles come with a 1 mL dropper for easy administering. These 1 mL droppers typically contain 20 drops of liquid. Most packaging will identify the mg/mL concentration of CBD and other cannabinoids. Still, because of the lack of regulation and inconsistent state laws, that is not always the case. To administer CBD more accurately, it can be useful to know the amount of CBD per drop. Let's look at an example:


Our MEDGRADES 1000 chocolate tincture contains:

1000mg of CBD per bottle = 33.3 mg of CBD per mL = 1.66 mg of CBD per drop


Dosage Formula

To determine the exact dosage of tincture that is right for you, fill in this formula:



Identifying your DESIRED STRENGTH Multiplier:

The last piece of the puzzle when determining the correct dose identifies the "Desired Strength" multiplier. This part of the formula can be subjective, but we will do our best to provide some guidance based on what we have heard from our customers.


For Mild Symptoms, Consider a Low Dose; Multiplier = (.1 )

Some of the conditions that our customers have considered mild symptoms include

· Mild to Moderate Stress

· Sore Muscles From Excercise

· Some Forms of Mild Seizures

· Light Sleepers


For Moderate Symptoms, Consider an Average Dose Multiplier = (.3 )

Some of the conditions that our customers have considered moderate symptoms include:

· Recurring Aches & Pains

· Arthritis & Joint Pain

· Sports Injuries

· PMS Pain & Cramps

· Lower Back Pain


For Heavy Symptoms, Consider a Strong Does Multiplier = (.6 )

Some of the conditions that our customers have considered severe symptoms include:

· Nerve Pain

· Chronic Pain

· Diabetic Neuropathy

· Cancer Treatment Pain


Some Final Thoughts

Some individuals quickly feel the painkilling effects of CBD oil; others need to take the oil for several days or even weeks before any change is detected. The time it takes for the transition to be felt depends on the underlying condition causing the discomfort and the individual's body chemistry. Today, the National Institute of Health hosts more than 14,000 published medical articles and scientific reports that discuss the health effects of CBD.


While we do not yet have enough data to conduct a systematic review of (homogeneous) randomized controlled trials, we are headed in that direction. Many of the cohort studies that have been conducted thus far are showing promising results. As federal cannabis legislation becomes a real possibility, the future looks bright for cannabis research and the future for cannabidiol, CBD.


We hope you find this article helpful in determining your ideal dose of CBD. Don't forget, everyone reacts to CBD differently. If you are trying CBD for the first time and unsure if it is really working, give it some time. We encourage you to take some form of CBD consistently for at least 2 weeks before deciding whether or not it is right for you.


If you are looking for the highest-quality CBD products for anxiety, pain, stress, inflammation, cramps, and a better night's sleep, try our most popular MEDGRADES 1000 CBD tincture. It comes in a Chocolate or Natural Flavor. If you are a first time customer, you can use coupon code "FIRST" at check out to receive a 10% discount.